Quick Answer
No, ibuprofen is NOT recommended during pregnancy, especially after 20 weeks. The FDA advises avoiding all NSAIDs (including ibuprofen, Advil, and Motrin) after 20 weeks due to risks of kidney problems in the baby.
Safer alternative: Acetaminophen (Tylenol) is generally considered safe throughout pregnancy when used as directed.
Safe Alternatives
Acetaminophen (Tylenol)
First-line choice for pain and fever during pregnancy.
- • Generally considered safe throughout pregnancy
- • Use the lowest effective dose
- • Don't exceed 3,000 mg per day
Trimester-by-Trimester Risks
First Trimester
Some studies suggest a possible slightly increased risk of miscarriage. Best to avoid.
Second & Third Trimester (After 20 weeks)
Do not use. Can cause low amniotic fluid levels and heart issues in the baby (premature closure of the ductus arteriosus).
Medical Review
Reviewed by: Ricardo Hamilton, MD
Last Updated: January 7, 2026
Sources: FDA Drug Safety Communication, American College of Obstetricians and Gynecologists (ACOG)