Quick Answer
No, ibuprofen is NOT recommended during pregnancy, especially after 20 weeks (mid-second trimester). The FDA advises avoiding all NSAIDs (including ibuprofen, Advil, and Motrin) after 20 weeks due to risks of kidney problems in the baby and complications with amniotic fluid.
Safer alternative: Acetaminophen (Tylenol) is generally considered safe throughout pregnancy when used as directed.
Trimester-by-Trimester Guidelines
First Trimester (Weeks 1-13)
Use with caution, only if necessary. Some studies suggest a possible increased risk of miscarriage with NSAID use in early pregnancy, though evidence is mixed.
Recommendation: Avoid unless specifically directed by your healthcare provider. Use acetaminophen instead.
Second Trimester (Weeks 14-27)
Avoid after week 20. After 20 weeks of pregnancy, the FDA issued a warning that NSAIDs can cause rare but serious kidney problems in the unborn baby, leading to low amniotic fluid levels.
Recommendation: Do not use ibuprofen after 20 weeks of pregnancy.
Third Trimester (Weeks 28-40)
Absolutely avoid. Ibuprofen in late pregnancy can cause:
- • Premature closure of the ductus arteriosus (important blood vessel in baby's heart)
- • Low amniotic fluid (oligohydramnios)
- • Kidney problems in the baby
- • Delayed labor
- • Increased bleeding risk during delivery
⚠️ Do NOT take ibuprofen in the third trimester.
What About Other NSAIDs?
The same warnings apply to all non-steroidal anti-inflammatory drugs (NSAIDs), including:
- • Naproxen (Aleve)
- • Aspirin (except low-dose as prescribed)
- • Celecoxib (Celebrex)
- • Indomethacin
- • Ketoprofen
- • Meloxicam (Mobic)
Safe Alternatives for Pain During Pregnancy
✓ Acetaminophen (Tylenol)
First-line choice for pain and fever during pregnancy.
- • Generally considered safe throughout pregnancy
- • Use the lowest effective dose
- • Don't exceed 3,000 mg per day
- • Not recommended for long-term daily use without doctor guidance
Non-Medication Options
For headaches: Rest, cold compress, hydration, prenatal massage
For back pain: Pregnancy pillow, prenatal yoga, physical therapy, warm baths
For muscle aches: Gentle stretching, warm compress, rest
For minor aches: Proper posture, supportive shoes, frequent position changes
What If I Already Took Ibuprofen?
Don't panic if you took ibuprofen before knowing you were pregnant or before 20 weeks.
Occasional, short-term use of ibuprofen in early pregnancy (especially before you knew you were pregnant) is unlikely to cause harm. The risks increase with:
- • Regular or prolonged use
- • Use after 20 weeks
- • High doses
Action to take: Stop taking ibuprofen now and contact your healthcare provider to discuss. They can assess any potential concerns and monitor your pregnancy appropriately.
When to Call Your Doctor
Contact your healthcare provider if:
- • You've been regularly taking ibuprofen during pregnancy
- • You need pain relief and acetaminophen isn't helping
- • You have severe or persistent pain
- • You have fever that doesn't respond to acetaminophen
- • You're unsure about any medication safety
Common Questions
Can I use ibuprofen gel or cream during pregnancy?
Topical NSAIDs are also generally not recommended during pregnancy, especially after 20 weeks, as they can still be absorbed into your bloodstream and potentially affect the baby.
Is aspirin safe during pregnancy?
Low-dose aspirin (81 mg) is sometimes prescribed by doctors for specific pregnancy conditions like preeclampsia prevention. However, regular-strength aspirin should be avoided, especially in the third trimester. Only take aspirin if specifically prescribed by your healthcare provider.
Can I take ibuprofen while breastfeeding?
Yes, ibuprofen is generally considered safe while breastfeeding as only small amounts pass into breast milk. It's actually preferred over acetaminophen by some breastfeeding mothers because it also reduces inflammation.
Medical Review
Reviewed by: Ricardo Hamilton, MD
Last Updated: November 26, 2025
Sources: FDA Drug Safety Communication (2020), American College of Obstetricians and Gynecologists (ACOG), MotherToBaby, Journal of the American Medical Association
Medical Disclaimer: This information is for educational purposes only. Always consult with your healthcare provider before taking any medication during pregnancy. Every pregnancy is different, and your doctor can provide personalized advice based on your specific situation.